Mucosal leishmaniasis: epidemiological and treatment considerations
DOI:
https://doi.org/10.5712/rbmfc6(18)145Keywords:
Leishmaniasis, Mucous Membrane, mucocutaneousAbstract
In South Brazil, American tegumentary leishmaniasis is predominant at Paraná, specially on the North and West areas, where it is localized one of the disease’s production circuits. It is believed that 3 to 5% of the cases evolve to the mucosal form, and that 1% of these can evolve to death. There is a long time that first choice drugs to treat this disease are the antimony compounds as pentavalent salts. The purpose of this study was to describe epidemiological and treatment characteristics of patients with mucosal leishmaniasis, who were diagnosed during the period from 2001 to 2007 in cities located on the coverage area of the 13 Heath Regional, which is situated in Cianorte, Paraná. The data were collected at the outpatient medical records and the System of Notifications and Information of Diseases epidemiological investigation records. During the mentioned period, 505 cases of American tegumentary leishmaniasis were notified, 30 of them (6%) as the mucosal form. In this study, the patients included were those with diagnosis of mucosal leishmaniasis that had complementary exams performed before and during the treatment. The results showed the need of patients’ careful monitoring by health teams, due to the possible evolution of the disease and the presence of unwanted drug effects.Downloads
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Brasil. Ministério da Saúde. Secretaria de vigilância em Saúde. Departamento de Vigilância Epidemiológica. Atlas de Leishmaniose tegumentar Americana: Diagnóstico clínico e diferencial. Brasília: Editora do Ministério da Saúde; 2006. 136 p.
Amato VS, Tuon FF, Siqueira AM, Nicodemo AC, Amato Neto V. Treatment of Mucosal Leishmaniasis in Latin America: Systematic Review. Am J Trop Med Hyg. 2007;77(2):266-74. DOI: https://doi.org/10.4269/ajtmh.2007.77.266
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância Epidemiológica. Manual de Vigilância da Leishmaniose Tegumentar Americana. Brasília: Editora do Ministério da Saúde; 2007. 182 p.
Tuon FF, Gomes-Silva A, Da-Cruz AM, Duarte MIS, Amato Neto V, Amato VS. Local immunological factors associated with recurrence of mucosal leishmaniasis. Clinical Immunology. 2008;128(3):442-6. DOI: https://doi.org/10.1016/j.clim.2008.05.007
Marsden PD. Mucosal leishmaniasis. Trans R Soc Trop Med Hyg. 1986;(80):859-76. DOI: https://doi.org/10.1016/0035-9203(86)90243-9
Sampaio RNR, Rocha RAA, Marsden PP, Cuba CC, Barreto AC. Leishmaniose tegumentar americana: casuística do hospital da UNB. An Bras Dermatol. 1980;55(2):69-76.
Lima MVN, Oliveira RZ, Lima AP, Felix MLO, Silveira TGV, Rossi RB, et al. Atendimento de pacientes com leishmaniose tegumentar americana: avaliação dos serviços de saúde de municípios do Noroeste do estado do Paraná, Brasil. Cad Saúde Pública. 2007 dez.;23(12):2938-48. DOI: https://doi.org/10.1590/S0102-311X2007001200015
Teodoro U, Spinoza RP, Vicente LSF, Guilherme ALF, Lima AP, Junqueira GMB, et al. Da necessidade de se adotar e divulgar esquemas terapêuticos para tratamento de leishmaniose tegumentar no Paraná. Rev. Inst. Med. Trop. S. Paulo. 1991 jun.;33(3):199-294. DOI: https://doi.org/10.1590/S0036-46651991000300006
Follador I, Araújo C, Cardoso MA, Tavares-Neto J, Barral A, Carvalho EM, et al. Surto de leishmaniose tegumentar americana em Canoa, Santo Amaro, Bahia, Brasil. Rev Soc Bras Med Trop. 1999 out.;32(5): 497-503. DOI: https://doi.org/10.1590/S0037-86821999000500005
Diógenes MJM, Gonçalves HS, Lima JW, Menezes RHO, Gonçalves HMG. Leishmanioses na infância: aspectos epidemiológicos, clínicos e de tratamento. An Bras Dermatol. 1993;(60):209-12.
Brasil. Ministério da Saúde. Fundação Nacional de saúde. Manual de controle da Leishmaniose Tegumentar Americana; 2000.
Gasser RA Jr, Magill AJ, Oster CN, Franke ED, Grögl M, Berman JD. Pancreatitis induced by pentavalent by pentavalent antimonial agents during treatment of leishmaniasis. Clin Infect Dis. 1994 Jan; 18(1): 83-90. DOI: https://doi.org/10.1093/clinids/18.1.83
Dietze R. Leishmaniose tegumentar americana. In: Cimerman S, Cimerman B. Medicina Tropical. (Ed.) São Paulo: Atheneu; 2005. p.1543-57.
Chulay LD, Spencer HC, Mugambi M. Eletrocardiographic changes during treatment of leishmaniasis with pentavalent antimony (sodium stibogluconate). Am J Trop Med Hyg. 1985;34(4):702-9. DOI: https://doi.org/10.4269/ajtmh.1985.34.702
Oliveira RZ, Oliveira LZ, Nunes CS, Limas MVN, Lima AP, Cerino D, et al. Leishmaniose cutânea e implicações do tratamento. III Congresso Internacional de Saúde; Maringá: Universidade Estadual de Maringá; 2009.
Lima MVN, Oliveira RZ, Lima AP, Cerino DA, Silveira TGV. Leishmaniose cutânea com desfecho fatal durante o tratamento com antimonial pentavalente. An Bras Dermatol. 2007;82(3):269-71. DOI: https://doi.org/10.1590/S0365-05962007000300010
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