Prevalence of nonalcoholic fatty liver disease and alcoholism in the participants of the Physical Activity in Community Project
DOI:
https://doi.org/10.5712/rbmfc6(18)97Keywords:
Fatty Liver, Obesity, AlcoholismAbstract
Screening image studies have shown that the frequency of hepatic steatosis findings has been progressivly increasing. The risk of developing NAFLD has been described and associated with obesity, insulin resistance and metabolic syndrome. There seems to be a correlation between NAFLD, alcohol e hepatic fibrosis. Our objective was to describe the prevalence of NAFLD and alcoholism in the participants of the of the Physical Activity in Community Project and to evaluate the associations between hepatic steatosis and presence of obesity and visceral obesity. Abdominal ultrasound was performed in 69 patients, 53.02±1.26 years old, looking for the presence and for the degree of fatty liver as well as subcutaneous and visceral fat. Patients with viral hepatitis and significant alcoholism were excluded after the AUDIT test. After this analysis, 60 patients were evaluated according to their anthropometrics data and were allocated into two groups: with and without fatty liver disease. The prevalence of alcoholism was 8.7%. Thirty seven percent of the patients showed up with NAFLD and were considered low to moderate risk (91%). The NAFLD showed a significant rise in the body mass index (34.1±8.7 versus 29.8±6.5kg/m2), waist circumference (102,6±12,7 versus 95.3±12.3cm), overall weight, (85,8±18,7 versus 74,5± 17.7kg), and visceral fat (47.9±10.5 versus 36.0±12.7mm). Hepatic steatosis is common in obese, especially in those with visceral obesity. We know that alcohol and visceral obesity are involved in the physiopathologic process of hepatic steatosis. For this reason, patients with Hepatic steatosis and excessive alcohol consumption may be at greater risk for Cirrhossis and hepatic insufficiency.Downloads
Metrics
References
Sheth SG, Gordon FD, Chopra S. Nonalcoholic steato-hepatitis. Ann Intern Med. 1997;126:137-45. DOI: https://doi.org/10.7326/0003-4819-126-2-199701150-00008
Angulo P. Nonalcoholic fatty liver disease. N Engl J Med. 2002;346: 1221-31. DOI: https://doi.org/10.1056/NEJMra011775
Sass DA, Chang P, Chopra KB. Nonalcoholic fatty liver disease: a clinical review. Dig Dis Sci. 2005;50:171-80. DOI: https://doi.org/10.1007/s10620-005-1267-z
Neuschwander-Tetri BA, Brunt EM, Whwmwier KR, Oliver D, Bacon BR. Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone. Hepatology. 2003;38(4): 1008-17. DOI: https://doi.org/10.1002/hep.1840380427
Carvalheira JBC, Saad MJA. Doenças associadas à resistência à insulina/hiperinsulinemia, não incluídas na síndrome metabólica. Arq Bras Endocrinol Metab. 2006 abr; 50(2):360-7. DOI: https://doi.org/10.1590/S0004-27302006000200022
Gaemers, IC, Groen AK. Novos esclarecimentos sobre a patogênese da doença gordurosa não-alcoólica do fígado. Current Opinion in Lipidology. 2006;17:268-73. DOI: https://doi.org/10.1097/01.mol.0000226118.43178.98
Pitella AM, Nazar A, Oliveira F, Maluly VG, d’Almeida e Silva F, Mexas PP. Esteato-hepatite não alcoólica (EHNA) como co-fator de agravamento das hepatopatias. Informativo Med’Dor. 2006;6:6-7.
Carraro, LM Godoy-Matos A, Guedes EP, Lopes,AC. Obesidade: Etiologia. In: ABESO. Projeto Diretrizes Brasileiras de Obesidade; 2007. p. 19-26.
Monteiro CA, Conde WL. A tendência secular da obesidade segundo estratos sociais: Nordeste e Sudeste do Brasil, 1975-1989-1997. Arq Bras Endoc Metab. 1999;43:186-94. DOI: https://doi.org/10.1590/S0004-27301999000300004
Instituto Brasileiro de Geografia e Estatística (IBGE) [internet]. Pesquisa de orçamentos familiares, período 2002-2003. Tabela 1: Prevalência de déficit de peso, excesso de peso e obesidade na população com 20 anos de idade ou mais, por sexo, segundo Unidade da Federação, áreas urbanas do Municípios das Capitais e Regiões Metropolitanas. [acesso em 2006 Abr 7]. Disponível em: www.ibge.gov.br/home/estatistica/ populacao.
Laranjeiras R, Pinsky I. O Alcoolismo. 5. ed. São Paulo: Contexto; 1998.
Figlie NB, Laranjeira R, Bordin S. Aconselhamento em dependência química. São Paulo: Roca, 2004.
Babor TF, Grant M. Project on identification and management of alcohol-related problems: report on phase II. A randomized clinical trial of brief interventions in primary health care. Geneva: WHO; 3. Bien TH, Miller WR, Tonigan JS. Brief Interventions for Alcohol Problems: a review. Add.1993;88:315-35.
Saunders BJ, Aasland OG, Babor TF, De La Fuente RJ, Grant M. Development of the Alcohol Use Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmfulk Alcohol Consumption - 11. Alc and Addic. 1993;88:791-804. DOI: https://doi.org/10.1111/j.1360-0443.1993.tb02093.x
Méndez EB, Lima MS, Olinto MTA, Farreli M [internet]. Uma versão brasileira do AUDIT. 13° Congresso Brasileiro de Alcoolismo e Outras Dependências; 1999. [Acesso em 01/09/2007]. Disponível em http:// br.monografias.com/trabalhos/pessoas-audit-tratamento-alcoolismo/ pessoas-audit-tratamento-alcoolismo 2shtml.
Moll AJ. Esteatose hepática - Avaliação por ultra-sonografia. Informativo Med’Dor. 2006;6:6-7.
Mancini MC, Halpern A. Obesidade: como diagnosticar e tratar. Rev Med Bras. 2006;63:132-43.
Gomes MB, Giannella Neto D, Mendonça E, Tambascia MA, Fonseca RM, Réa RR et al. Prevalência de Sobrepeso e Obesidade em pacientes com Diabetes Mellitus do Tipo 2 no Brasil: Estudo Multicêntrico Nacional. Arq Bras Endocrinol Metab. 2006; 50/1:136-44. DOI: https://doi.org/10.1590/S0004-27302006000100019
Benchimol KB, Cardoso IS. Esteatohepatite não-alcoólica induzida por rápida perda de peso em uso de balão intragástrico: um relato de caso. Arq Bras Endocrinol Metab. 2007;51:631-4. DOI: https://doi.org/10.1590/S0004-27302007000400019
Teixeira RJ, Simão Y, Anderson MIP. Abordagem da Síndrome Metabólica. PROMEF 2006;ciclo 1(2):95-124.
Godoy-Matos AF, Moreira RO. Síndrome metabólica: implicações clínicas e tratamento. In: Vilar L (Ed.). Endocrinologia Clínica. 3. ed. Rio de Janeiro: Guanabara Koogan; 2006. p. 266-74.
Pouliot MC, Despres JP, Lemieux S, Moorjani S, Bouchard C, Tremblay A, et al. Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. Am J Cardiol. 1994;73:460-8. DOI: https://doi.org/10.1016/0002-9149(94)90676-9
Soler GLN, Silva AWSM, Silva VCG, Teixeira RJ. Doença hepática gordurosa não-alcoólica: associação com síndrome metabólica e fatores de risco cardiovascular. Rev SOCERJ. 2008;2(2):94-100.
Matos AFG, Moreira RO. Síndrome metabólica: do diagnóstico ao tratamento. Diabetes mellitus. In: Lyra R, Cavalcante Ney (Ed.). Diabetes Mellitus. São Paulo: Atlanta; 2006. p. 171-82.
Monteiro CA, Mondini L, Souza ALM, Popkin BM. The nutrition transition in Brazil. Eur J Clin Nutr. 1995;49:105-13.
Grundy SM. Metabolic syndrome: connecting and reconciling cardiovascular and diabetes worlds. JACC. 2006;47:1093-100. DOI: https://doi.org/10.1016/j.jacc.2005.11.046
Siebler J, Galle PR. Treatment of nonalcoholic fatty liver disease. World J Gastroenterol. 2006;12:2161-7.
Meriño-Ibarra E, Artieda M, Cenarro A, Goicoechea J, Calvo L, Guallar A, et al. Ultrasonography for the evaluation of visceral fat and the metabolic syndrome. Metabolism Clinical and Experimental. 2005;54(9):1230-5. DOI: https://doi.org/10.1016/j.metabol.2005.04.009
Bau CHD [internet]. Estado atual e perspectivas da genética e epidemiologia do alcoolismo. [citado 2007 Maio 23]. Ciên Saúde Col. 2002;7:183-90. Disponível em: http://www.scielo.br/pdf/csc/v7n1/ a17v07n1.pdf. DOI: https://doi.org/10.1590/S1413-81232002000100017
Downloads
Published
How to Cite
Issue
Section
License
By submitting a manuscript to the RBMFC, authors retain ownership of the copyright in the article, and authorize RBMFC to publish that manuscript under the Creative Commons Attribution 4.0 license and identify itself as the vehicle of its original publication.