Cytology screening for anal cancer in men who have sex with men

rapid review

Authors

DOI:

https://doi.org/10.5712/rbmfc19(46)4206

Keywords:

Early detection of cancer, Anal neoplasms, Sexual and gender minorities.

Abstract

Introduction: Screening for precancerous lesions has been proposed as a preventive measure for anal cancer in at-risk populations. Objective: To conduct a rapid literature review to gather evidence on screening in men who have sex with men (MSM). Methods: A rapid review was conducted using the PubMed® platform from October to November 2022. Results: Ten studies were selected for analysis (n=7,694). Study designs included three prospective cohorts, four retrospective cohorts, two case-control studies, and one cross-sectional study, conducted in five countries. Conclusions: The studies reviewed highlight the importance of anal cytology as a screening tool for anal cancer in MSM living with HIV, as well as the need for further research to elucidate its efficacy in other subpopulations and HIV-negative MSM.

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References

Barroso LF, Stier EA, Hillman R, Palefsky J. Anal Cancer Screening and Prevention: Summary of Evidence Reviewed for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infection Guidelines. Clin Infect Dis 2022;74(Suppl_2):S179-S192. https://doi.org/10.1093/cid/ciac044 DOI: https://doi.org/10.1093/cid/ciac044

Johnson LG, Madeleine MM, Newcomer LM, Schwartz SM, Daling JR. Anal cancer incidence and survival: the surveillance, epidemiology, and end results experience, 1973-2000. 2004;101(2):281-8. https://doi.org/10.1002/cncr.20364 DOI: https://doi.org/10.1002/cncr.20364

Shiels MS, Pfeiffer RM, Chaturvedi AK, Kreimer AR, Engels EA. Impact of the HIV epidemic on the incidence rates of anal cancer in the United States. J Natl Cancer Inst 2012;104(20):1591-8. https://doi.org/10.1093/jnci/djs371 DOI: https://doi.org/10.1093/jnci/djs371

Clifford GM, Georges D, Shiels MS, Engels EA, Albuquerque A, Poynten IM, et al. A meta-analysis of anal cancer incidence by risk group: Toward a unified anal cancer risk scale. Int J Cancer 2021;148(1):38-47. https://doi.org/10.1002/ijc.33185 DOI: https://doi.org/10.1002/ijc.33185

Hirsch BE, Fine SM, Vail R, McGowan JP, Merrick ST, Radix A, et al. Screening for Anal Dysplasia and Cancer in Adults With HIV. Baltimore: Johns Hopkins University; 2022.

Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de DST, Aids e Hepatites Virais. O Manejo da Infecção pelo HIV na Atenção Básica: Manual para Profissionais Médicos. Brasília: Ministério da Saúde; 2015. 24 p.

Brasil. Ministério da Saúde. Secretaria de Ciência, Tecnologia, Inovação e Insumos Estratégicos em Saúde. Departamento de Gestão e Incorporação de Tecnologias em Saúde. Diretrizes metodológicas: elaboração de revisão sistemática e meta-análise de ensaios clínicos randomizados. Brasília: Ministério da Saúde; 2021. 93 p.

Gaisa M, Sigel K, Hand J, Goldstone S. High rates of anal dysplasia in HIV-infected men who have sex with men, women, and heterosexual men. AIDS 2014;28(2):215-22. https://doi.org/10.1097/QAD.0000000000000062 DOI: https://doi.org/10.1097/QAD.0000000000000062

Gandra S, Azar A, Wessolossky M. Anal high-risk human papillomavirus infection and high-grade anal intraepithelial neoplasia detected in women and heterosexual men infected with human immunodeficiency virus. HIV/AIDS (Auckl) 2015;7:29-34. https://doi.org/10.2147/HIV.S73880 DOI: https://doi.org/10.2147/HIV.S73880

DʼSouza G, Wentz A, Wiley D, Shah N, Barrington F, Darragh TM, et al. Anal Cancer Screening in Men Who Have Sex With Men in the Multicenter AIDS Cohort Study. J Acquir Immune Defic Syndr 2016;71(5):570-6. https://doi.org/10.1097/QAI.0000000000000910 DOI: https://doi.org/10.1097/QAI.0000000000000910

Jin F, Grulich AE, Poynten IM, Hillman RJ, Templeton DJ, Law CLH, et al. The performance of anal cytology as a screening test for anal HSILs in homosexual men. Cancer Cytopathol 2016;124(6):415-24. https://doi.org/10.1002/cncy.21702 DOI: https://doi.org/10.1002/cncy.21702

Frank M, Lahiri CD, Nguyen ML, Mehta CC, Mosunjac M, Flowers L, et al. Factors Associated with High-Grade Anal Intraepithelial Lesion in HIV-Positive Men in a Southern U.S. City. AIDS Res Hum Retroviruses 2018;34(7):598-602. https://doi.org/10.1089/AID.2018.0008 DOI: https://doi.org/10.1089/aid.2018.0008

Pernot S, Boucheron P, Péré H, Lucas ML, Veyer D, Fathallah N, et al. Comparison of anal cancer screening strategies including standard anoscopy, anal cytology, and HPV genotyping in HIV-positive men who have sex with men. Br J Cancer 2018;119(3):381-6. https://doi.org/10.1038/s41416-018-0176-9 DOI: https://doi.org/10.1038/s41416-018-0176-9

Thompson AB, Gillespie SE, Mosunjac MB, Hussen SA, Flowers LC, Camacho-Gonzalez AF, et al. Prevalence of Anal Squamous Intraepithelial Lesions in HIV-1-Infected Young Men Who Have Sex With Men and Transwomen. J Low Genit Tract Dis 2018;22(4):340-7. https://doi.org/10.1097/LGT.0000000000000437 DOI: https://doi.org/10.1097/LGT.0000000000000437

Wang CC, Chang SL, Chu FY, Cheng CY, Cheng SH, et al. Human papillomavirus infection and anal cytology in Taiwanese homosexual men with and without HIV infection. J Infect Dev Ctries 2019;13(4):318-25. https://doi.org/10.3855/jidc.11162 DOI: https://doi.org/10.3855/jidc.11162

Gaisa MM, Sigel KM, Deshmukh AA, Lenskaya V, Chan CA, Silvera R, et al. Comparing Anal Cancer Screening Algorithms Using Cytology and Human Papillomavirus DNA Testing in 3 High-Risk Populations. J Infect Dis 2021;224(5):881-8. https://doi.org/10.1093/infdis/jiaa801 DOI: https://doi.org/10.1093/infdis/jiaa801

Blair KJ, Martínez-Vernaza S, Ordóñez-Blanco IT, Hernandez W, Quiroga C, Lowenstein E, et al. Screening with Anal Cytology in Colombia: Initial Experience and Need for High-Resolution Anoscopy. J Surg Res 2021;267:374-83. https://doi.org/10.1016/j.jss.2021.05.037 DOI: https://doi.org/10.1016/j.jss.2021.05.037

Park IU, Palefsky JM. Evaluation and Management of Anal Intraepithelial Neoplasia in HIV-Negative and HIV-Positive Men Who Have Sex with Men. Curr Infect Dis Rep 2010;12(2):126-33. https://doi.org/10.1007/s11908-010-0090-7 DOI: https://doi.org/10.1007/s11908-010-0090-7

Goldstone SE, Moshier E. Detection of oncogenic human papillomavirus impacts anal screening guidelines in men who have sex with men. Dis Colon Rectum 2010;53(8):1135-42. https://doi.org/10.1007/DCR.0b013e3181e10842 DOI: https://doi.org/10.1007/DCR.0b013e3181e10842

Hillman RJ, Cuming T, Darragh T, Nathan M, Berry-Lawthorn M, Goldstone S, et al. 2016 IANS International Guidelines for Practice Standards in the Detection of Anal Cancer Precursors. J Low Genit Tract Dis 2016;20(4):283-91. https://doi.org/10.1097/LGT.0000000000000256 DOI: https://doi.org/10.1097/LGT.0000000000000256

Goldie SJ, Kuntz KM, Weinstein MC, Freedberg KA, Palefsky JM. Cost-effectiveness of screening for anal squamous intraepithelial lesions and anal cancer in human immunodeficiency virus-negative homosexual and bisexual men. Am J Med 2000;108(8):634-41. https://doi.org/10.1016/s0002-9343(00)00349-1 DOI: https://doi.org/10.1016/S0002-9343(00)00349-1

Patel P, Bush T, Kojic EM, Conley L, Unger ER, Darragh TM, et al. Prevalence, Incidence, and Clearance of Anal High-Risk Human Papillomavirus Infection Among HIV-Infected Men in the SUN Study. J Infect Dis 2018;217(6):953-63. https://doi.org/10.1093/infdis/jix607 DOI: https://doi.org/10.1093/infdis/jix607

Poynten IM, Jin F, Roberts JM, Templeton DJ, Law C, Cornall AM, et al. The Natural History of Anal High-grade Squamous Intraepithelial Lesions in Gay and Bisexual Men. Clin Infect Dis 2021;72(5):853-61. https://doi.org/10.1093/cid/ciaa166 DOI: https://doi.org/10.1093/cid/ciaa166

Machalek DA, Poynten M, Jin F, Fairley CK, Farnsworth A, Garland SM, et al. Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis. Lancet Oncol 2012;13(5):487-500. https://doi.org/10.1016/S1470-2045(12)70080-3 DOI: https://doi.org/10.1016/S1470-2045(12)70080-3

Palefsky JM, Lee JY, Jay N, Goldstone SE, Darragh TM, Dunlevy HA, et al. Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer. N Engl J Med 2022;386(24):2273-82. https://doi.org/10.1056/NEJMoa2201048 DOI: https://doi.org/10.1056/NEJMoa2201048

Daling JR, Madeleine MM, Johnson LG, Schwartz SM, Shera KA, Wurscher MA, et al. Human papillomavirus, smoking, and sexual practices in the etiology of anal cancer. Cancer 2004;101(2):270-80. https://doi.org/10.1002/cncr.20365 DOI: https://doi.org/10.1002/cncr.20365

Russo S, Mccaffery K, Ellard J, Poynten M, Prestage G, Templeton DJ, et al. Experience and psychological impact of anal cancer screening in gay, bisexual and other men who have sex with men: a qualitative study. Psychooncology 2018;27(1):125-31. https://doi.org/10.1002/pon.4480 DOI: https://doi.org/10.1002/pon.4480

BRASIL. Ministério da Saúde. Secretaria de Gestão Estratégica e Participativa. Departamento de Apoio à Gestão Participativa. Política Nacional de Saúde Integral de Lésbicas, Gays, Bissexuais, Travestis e Transexuais. 1ª ed., 1. reimp. Brasília: Ministério da Saúde; 2013. 32 p.

Published

2024-12-10

How to Cite

1.
Oliveira LML de, Corrêa FAD. Cytology screening for anal cancer in men who have sex with men: rapid review. Rev Bras Med Fam Comunidade [Internet]. 2024 Dec. 10 [cited 2024 Dec. 19];19(46):4206. Available from: https://rbmfc.org.br/rbmfc/article/view/4206

Issue

Section

Especial Residência Médica

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