Prevalence and factors associated with potential drug interactions among elderly in a population-based study

Authors

  • Daniel Riani Gotardelo Instituto Metropolitano de Ensino Superior (IMES). Ipatinga, MG,
  • Lorena Silva Fonseca Instituto Metropolitano de Ensino Superior (IMES). Ipatinga, MG,
  • Eugênio Rodrigues Masson Instituto Metropolitano de Ensino Superior (IMES). Ipatinga, MG,
  • Lauro Nogueira Lopes Instituto Metropolitano de Ensino Superior (IMES). Ipatinga, MG,
  • Vinícius Nogueira Toledo Instituto Metropolitano de Ensino Superior (IMES). Ipatinga, MG,
  • Marina Abreu Faioli Instituto Metropolitano de Ensino Superior (IMES). Ipatinga, MG,
  • Aline Martins de Melo Meira Instituto Metropolitano de Ensino Superior (IMES). Ipatinga, MG,
  • Cássia Kelly Martins Costa Instituto Metropolitano de Ensino Superior (IMES). Ipatinga, MG,
  • Raíssa Braga Linhares Andrade Instituto Metropolitano de Ensino Superior (IMES). Ipatinga, MG,

DOI:

https://doi.org/10.5712/rbmfc9(31)833

Keywords:

Drug Interactions, Aged, Health of the Elderly, Family Health Strategy, Primary Health Care

Abstract

Objectives: The aim of this study was to determine the prevalence of potential drug interactions and the factors associated with them among elderly patients covered by the Family Health Strategy in the municipality of Timóteo, state of Minas Gerais, Brazil. Methods: Cross-sectional study, using stratified random sampling. A total of 273 household interviews were conducted in subjects aged 60 years or older, after obtaining informed consent, using a questionnaire containing questions related to identification, demography, health conditions and medication use. Drug interactions were identified and classified according to the software Micromedex®. Results: The overall prevalence of potential drug interactions was 55.6%, a total of 466 cases, of which 5.6% were mild, 81.6% moderate and 12.8% of greater severity. Therapeutic classes most frequently involved were anti-inflammatory drugs and especially drugs used in cardiovascular disease. The absence of hospitalization in the last four months was significantly associated with a lower chance of serious drug interactions and most patients who did not have any moderate drug interactions used only drugs prescribed by physicians. Conclusions: The prevalence of potential drug interactions was similar to that described in the literature, demonstrating the high frequency of this phenomenon among the elderly. The absence of prior hospitalization and drug prescription by physicians were associated with a lower frequency of interactions. The prescription of multiple drugs simultaneously to elderly patients can compromise the safety and health of this population, requiring, by caregivers, observation for the occurrence of potential drug interactions.

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Author Biographies

Daniel Riani Gotardelo, Instituto Metropolitano de Ensino Superior (IMES). Ipatinga, MG,

Mestre em Farmacologia Clínica. Professor titular de Farmacologia Clínica e de Medicina de Família e Comunidade. Especialista em Medicina de Família e Comunidade (SBMFC).

Lorena Silva Fonseca, Instituto Metropolitano de Ensino Superior (IMES). Ipatinga, MG,

Estudante do curso de Medicina da Faculdade de Medicina do Vale do Aço (IMES/Univaço), Ipatinga, MG.

Eugênio Rodrigues Masson, Instituto Metropolitano de Ensino Superior (IMES). Ipatinga, MG,

Estudante do curso de Medicina da Faculdade de Medicina do Vale do Aço (IMES/Univaço), Ipatinga, MG.

Lauro Nogueira Lopes, Instituto Metropolitano de Ensino Superior (IMES). Ipatinga, MG,

Estudante do curso de Medicina da Faculdade de Medicina do Vale do Aço (IMES/Univaço), Ipatinga, MG.

Vinícius Nogueira Toledo, Instituto Metropolitano de Ensino Superior (IMES). Ipatinga, MG,

Estudante do curso de Medicina da Faculdade de Medicina do Vale do Aço (IMES/Univaço), Ipatinga, MG.

Marina Abreu Faioli, Instituto Metropolitano de Ensino Superior (IMES). Ipatinga, MG,

Estudante do curso de Medicina da Faculdade de Medicina do Vale do Aço (IMES/Univaço), Ipatinga, MG.

Aline Martins de Melo Meira, Instituto Metropolitano de Ensino Superior (IMES). Ipatinga, MG,

Estudante do curso de Medicina da Faculdade de Medicina do Vale do Aço (IMES/Univaço), Ipatinga, MG.

Cássia Kelly Martins Costa, Instituto Metropolitano de Ensino Superior (IMES). Ipatinga, MG,

Estudante do curso de Medicina da Faculdade de Medicina do Vale do Aço (IMES/Univaço), Ipatinga, MG.

Raíssa Braga Linhares Andrade, Instituto Metropolitano de Ensino Superior (IMES). Ipatinga, MG,

Estudante do curso de Medicina da Faculdade de Medicina do Vale do Aço (IMES/Univaço), Ipatinga, MG.

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Published

2014-04-24

How to Cite

1.
Gotardelo DR, Fonseca LS, Masson ER, Lopes LN, Toledo VN, Faioli MA, Meira AM de M, Costa CKM, Andrade RBL. Prevalence and factors associated with potential drug interactions among elderly in a population-based study. Rev Bras Med Fam Comunidade [Internet]. 2014 Apr. 24 [cited 2024 Dec. 22];9(31):111-8. Available from: https://rbmfc.org.br/rbmfc/article/view/833

Issue

Vol. 9 No. 31 (2014): Abril-Junho

Section

Research Articles

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By submitting a manuscript to the RBMFC, authors retain ownership of the copyright in the article, and authorize RBMFC to publish that manuscript under the Creative Commons Attribution 4.0 license and identify itself as the vehicle of its original publication.

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